SKM 2023 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 1: Membranes, Vesicles, Synthetic Cells

BP 1.9: Vortrag

Montag, 27. März 2023, 12:00–12:15, BAR Schö

Simulating transient pores in hemifused membranes — •Russell Spencer and Marcus Müller — Georg-August Universität Göttingen, Institute for Theoretical Physics, 37077 Göttingen, Germany

Transportation of material from one side of a hemifused membrane to another can be facilitated through the formation of transient pores, which open, allow the material to pass and then close. One important example of this occurs in the `kiss and run' (KAR) mechanism for transporting material from inside a vesicle in a cell to outside of the cell. The vesicle first fuses with the membrane, forming a hemifusion diaphragm (HD). A pore then opens in the HD allowing the material out, then the pore closes and the vesicle detaches. This process occurs in the release of neurotransmitters from a synapse into the post-synaptic cleft. This work uses self-consistent field theory and the string method to calculate the minimum free energy path for membrane fusion and the opening and closing of the transient pore. We also study the effects of proteins, which facilitate the process by altering the thermodynamics of pore formation.