SKM 2023 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 10: Evolution and Origin of Life

BP 10.1: Hauptvortrag

Dienstag, 28. März 2023, 09:30–10:00, BAR 0106

Protein evolution in sequence landscapes: from data to models and back — •Martin Weigt — Sorbonne University, Paris, France

In the course of evolution, proteins diversify their sequences via mutations, while keeping their 3D structure and biological functions remarkably conserved. Modern sequence databases provide us with increasingly large samples for this sequence diversity. In my talk, I will describe how these samples can be used to infer data-driven protein sequence landscapes, using approaches borrowed from statistical physics or machine learning. In turn, we can model the interplay between mutation and selection in protein evolution as a stochastic process in these landscapes. I will illustrate these ideas in three examples: (i) the prediction of the effect of individual mutations in proteins, (ii) the modeling of experimental protein evoltuion, and (iii) the statistical design of artificial but functional proteins.