SKM 2023 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 11: Poster Session I

BP 11.36: Poster

Dienstag, 28. März 2023, 12:30–15:30, P1

SAXS measurements during polychromatic illumination of photoswitching in azobenzene lipid vesicles — •Matthias Lösche¹, Benedikt Baumgartner², Benjamin Ajanovic¹, Oliver Thorn-Seshold², and Bert Nickel¹ — ¹Faculty of Physics and CeNS, Ludwig-Maximilians-Universiät München, Geschwister-Scholl-Platz 1, Munich 80539, Germany — ²Department of Pharmacy, Ludwig-Maximilians-Universität München, Butenandtstraße 5-13, Munich 81377, Germany

Photoswitchable molecules are envisioned to be used in the field of nanomedicine. Here we study photoswitchable azobenzene lipids which switch to predominantly cis-state at 365 nm wavelength illumination and to trans-state at 465 nm illumination. The conformational change of the lipid induces different vesicle membrane thicknesses, which can be read out by small-angle x-ray scattering, as established by us before. What is not yet known is how azobenzene lipid vesicles behave when irradiated at other wavelengths. We illuminate lipid vesicles with 16 different wavelengths (generated by high-power LEDs) which cover the whole visible light region. We follow the kinetics of the switching process by SAXS. This establishes an action spectrum that correlates the different photostationary states with illumination wavelength.