SKM 2023 – scientific programme

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BP: Fachverband Biologische Physik

BP 11: Poster Session I

BP 11.40: Poster

Tuesday, March 28, 2023, 12:30–15:30, P1

Wetting-effects of liquid-liquid condensates on lipid membranes — Chae Yeon Kang, Yoohyun Chang, and •Katja Zieske — Max Planck Institute for the Science of Light, Erlangen

Liquid-liquid condensates are supramolecular assemblies of proteins and RNA molecules and have been studied extensively, due to their ability to spatially structure cells and to spatially confine biological reactions. However, little is known about the interactions of liquid-liquid condensates with lipid membranes and the consequences of these interactions on cellular length scales.

Here, we used a cell-free bottom-up approach to reconstitute liquid-liquid condensates at lipid membranes. Our results demonstrate how lipid membranes and liquid-liquid condensates interact under various experimental conditions and point towards an important role of wetting-effects in intracellular organization.