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BP: Fachverband Biologische Physik

BP 11: Poster Session I

BP 11.74: Poster

Tuesday, March 28, 2023, 12:30–15:30, P1

A first approach for mimicking guided axon-growth by electrical circuits — •Bakr Al Beattie, Sebastian Jenderny, Karlheinz Ochs, and Dennis Michaelis — Ruhr University Bochum, Chair of Digital Communication Systems, Bochum, Germany

The self-organization aspect of electrical circuits mimicking neuronal networks often only focuses on synapses. Besides the adjustment of synaptic coupling strength, the guidance of growing axons is another important principle for the biological wiring process of neurons. In particular, guidance cues determine the growth direction and thus which neurons interconnect with each other. Up to now, only mathematical models of this process exist. Our aim hence is to provide an ideal electrical circuit mimicking fundamental principles of guided axon growth. For this purpose, we use memristors in combination with sensors. Here, the sensors represent the sensing of guidance cues, while the memristors form the non-volatile signal transmission paths. We then develop a corresponding wave digital model to verify our circuit approach.