SKM 2023 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 13: Signaling, Biological Networks

BP 13.1: Hauptvortrag

Mittwoch, 29. März 2023, 09:30–10:00, BAR 0106

Biological signal processing across scales — •Steffen Rulands — Ludwig-Maximilians Universität München, Arnold Sommerfeld Center ffor theoretical Physics, Theresienstr. 37, 80333 München — Max-Planck-Institute for theoretical Physics, Nöthnitzer Str. 38, 01187 Dresden

In contrast to many physical systems, biological systems have the remarkable architecture of being organized into a spatial hierarchy of non-equilibrium processes: from molecules embedded into sub-cellular compartments to cells interacting in tissues. In my talk, I will show how biological systems manipulate the transmission of noise and information between and across these scales in order to perform biological functions. By combining theory and experiments I will first describe a general theory describing the propagation of noise and signals in multi-scale non-equilibrium systems. I will then apply these insights to show how cells make use of the propagation of fluctuations on the subcellular scale to perform biological signal processing: by establishing a low-pass filter of concentration fluctuations in the regulation of cell death and by facilitating a gelation phase transition in the innate immune response.