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SKM 2023 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 15: Tissue Mechanics II

BP 15.2: Vortrag

Mittwoch, 29. März 2023, 10:45–11:00, BAR Schö

Noisy growth and buckling in soft tissues — •Rahul G. Ramachandran1, Ricard Alert1,2, and Pierre A. Haas1,2,31Max Planck Institute for the Physics of Complex System, 01187 Dresden, Germany — 2Center for Systems Biology Dresden, 01307 Dresden, Germany — 3Max Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany

The generation of curved tissue shapes such as the villi of the gut or the gyrations of the brain has been associated with buckling instabilities that release elastic stresses accumulated by constrained growth. However, most mechanical theories for these morphogenetic processes assume homogeneous growth and mechanical properties, while these parameters often exhibit strong fluctuations in biological systems. Here, we therefore study a minimal mechanical model of these fluctuations: We analyze the buckling of a growing, neo-Hookean rod through nonlinear finite-element simulations. Fluctuations are introduced as spatial inhomogeneities of the growth tensor and the material parameters. Our results show that stronger growth fluctuations promote buckling by decreasing the buckling threshold. We interpret these results using strain energy distribution from homogenous, patterned and random growth simulations and validate them using analytical calculations.

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