SKM 2023 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 27: Computational Biophysics II
BP 27.8: Vortrag
Donnerstag, 30. März 2023, 17:00–17:15, BAR 0106
Diffusive properties in simulations of polydisperse sphere mixtures mimicking the inside of a cell — •Frank Hirschmann1, Hender Lopez2, Felix Roosen-Runge3, and Martin Oettel1 — 1Institute for Applied Physics, University of Tübingen, Germany — 2School of Physics and Optometric & Clinical Sciences, Technological University Dublin, Ireland — 3Department of Biomedical Sciences and Biofilms-Research Center for Biointerfaces (BRCB), Malmö University, Sweden
The interiors of living cells contain a multitude of different-sized biomacromolecules at relatively high packing fractions. Diffusivity and transport properties in such crowded environments are highly influenced by hydrodynamic interactions. Thus, the time needed for proteins to come into contact with each other within the cell is determined by a complex interplay of polydispersity, size-distribution and crowding. In order to analyze such systems theoretically, we employ Brownian Dynamics (BD) simulations of polydisperse mixtures of hard spheres. Using results of Stokesian dynamics we approximate hydrodynamic interactions in our BD simulations by a simple multiplicative ansatz (equivalent to a hydrodynamic "renormalization" of the Brownian short-time diffusivity), which allows us to access the long-time limit of our system. We investigate resulting diffusion constants and survival probabilities, exhibiting non-trivial behavior.