SKM 2023 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 28: Poster Session II

BP 28.39: Poster

Donnerstag, 30. März 2023, 18:00–20:00, P2/EG

Motility of adherent cells on structured surfaces at elevated viscosities — •Radhakrishnan Adiyodi Veettil, Sebastian W Krauss, Annika A Vogler, Florian Rehfeldt, and Matthias Weiss — Experimental Physics I, University of Bayreuth, Germany

Cell motility is sensitive to the viscosity of the surrounding medium, suggesting that such external cues can trigger cells to switch gears. Indeed, it has been recently reported that elevated viscosities can induce significant changes in cell area, cell migration speed and focal adhesion turn over [1]. Here, we have followed up on these experiments by monitoring the viscosity-dependent migration of different cell types on microstructured surfaces, e.g. cell hopping of cancerous and non-cancerous cells in dumbbell patterns. Our data suggest that altering viscosity can markedly alter the migration dynamics of cells on microstructured surfaces.

[1] Pittman, Iu, Li et al., Nat. Phys. 18, 1112 (2022)