SKM 2023 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 4: Tissue Mechanics I
BP 4.6: Vortrag
Montag, 27. März 2023, 16:30–16:45, BAR Schö
Continuum Mechanics of Cell Intercalation in Tribolium — •Maryam Setoudeh1,2,3 and Pierre A. Haas1,2,3 — 1Max Planck Institute for the Physics of Complex Systems, Nöthnitzer Straße 38, 01187 Dresden, Germany — 2Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstraße 108, 01307 Dresden, Germany — 3Center for Systems Biology Dresden, Pfotenhauerstraße 108, 01307 Dresden, Germany
Deformations of tissues during development often involve cell intercalations and cell neighbour exchanges, but a general continuum description of such plastic rearrangements in tissues is still lacking.
Here, we combine morphoelasticity and plasticity theory to develop a continuum framework of tissue mechanics combining cell intercalations, intrinsic deformations such as tissue contraction, and elastic deformations of the tissue.
We apply our theory to the development of the beetle Tribolium [1] during which a layer of cells, the serosa, closes over the embryo. Cells deintercalate from the rim of the serosa into its bulk, thus reducing the number of cells at the boundary and closing the serosa. This is associated with actomyosin contraction at the rim of the serosa [1].
We model this process by the axisymmetric closure of a circular hole in a flat elastic sheet contracting near the hole. Our analytical and numerical results show how intercalation reduces the contraction required for serosa closure and hint at the importance of an additional force exerted by the embryo at the rim of the serosa.
[1] Jain et al., Nat. Commun. 11, 5604 (2020)