SKM 2023 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 8: Cell Mechanics I
BP 8.1: Vortrag
Dienstag, 28. März 2023, 09:30–09:45, BAR Schö
Chiral flows can drive pattern formation in viscoelastic surfaces — •Eloy de Kinkelder1,2, Elisabeth Fischer-Friedrich3,4, and Sebastian Aland1,2 — 1TU Bergakademie Freiberg, Freiberg, Germany — 2HTW Dresden, Dresden, Germany — 3TU Dresden, Dresden, Germany — 4BIOTEC, Dresden, Germany
During division in animal cells, the actomyosin cortex has been found to exhibit counter-rotating cortical flows along the axis of division. These are also known as chiral flows. Notably, the chiral flows were shown to influence cellular rearrangements and drive the left-right symmetry breaking in developing organisms. At the current state, no numerical simulations have been done to study the influence of chiral flows on the cell cortex shape. To deepen the insight on that matter, we present here a numerical study of an axi-symmetric viscoelastic surface embedded in a viscous fluid. On this surface we impose a generic counter rotating force field to investigate its influence on the surface shape and material transport. Notably, we find that a large areal relaxation time results in flows towards the equator of the surface. These flows assist the transport of a surface concentration during the forming of a contractile ring. Accordingly, we show that chiral forces by themselves can drive pattern formation and stabilise contractile rings at the equator.