SKM 2023 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 8: Cell Mechanics I
BP 8.3: Vortrag
Dienstag, 28. März 2023, 10:00–10:15, BAR Schö
Red blood cell lingering modulates hematocrit distribution in the microcirculation — •Yazdan Rashidi1, Greta Simionato2, Qi Zhou3, Thomas John1, Alexander Kihm1, Mohammed Bendaoud1, Timm Krueger3, Miguel o. Bernabeu3, Lars Kaestner1, Mattias w. Laschke2, Michael d. Menger2, Christian Wagner1, and Alexis Darras1 — 1Experimental Physics, Saarland University, 66123 Saarbruecken, Germany — 2Institute for Clinical and Experimental Surgery, Saarland University, 66421 Homburg, Germany — 3School of Engineering, University of Edinburgh, Edinburgh EH9 3FD, United Kingdom
The distribution of red blood cells (RBCs) in the microcirculation determines how oxygen is delivered to tissues and organs. This process relies on the partitioning of RBCs at successive microvascular bifurcations. It is known that RBCs partition disproportionately to the blood flow rate, therefore leading to heterogeneity of the hematocrit in microvessels. Usually, downstream of a bifurcation, the vessel branch with a higher fraction of blood flow receives a higher fraction of RBC flux.
However, deviations from this phase-separation law have been observed in recent works. Here, we quantify how the microscopic behavior of RBCs lingering influences their partitioning, through combined in vivo experiments and in silico simulations. We quantify the cell lingering at capillary-level bifurcations and demonstrate that it correlates with deviations from the phase-separation process from established empirical predictions by Pries et al.