SKM 2023 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 9: Active Matter III (joint session BP/CPP/DY)

BP 9.8: Vortrag

Dienstag, 28. März 2023, 11:30–11:45, TOE 317

Nucleation of chemically active droplets — •Noah Ziethen and David Zwicker — Max Planck Institute for Dynamics and Self-Organization, Göttingen, Germany

Liquid-liquid phase separation emerged as a crucial organizing principle inside biological cells giving rise to a plethora of intracellular compartments. Unique to the cellular context, these condensates can consist of only a few hundred molecules and are affected by non-equilibrium processes. In particular, active chemical conversion between condensate material and proteins in the surrounding cytoplasm can control multiple aspects of the condensates. Yet, it is unclear how these reactions affect the spontaneous nucleation and dissolution associated with low particle numbers. Here, we investigate the influence of chemical reactions on the bistable region of active droplets using a stochastic field theory. We find an effective increase in the energy barrier and thus decelerated transitions between the homogeneous and the droplet state. Using classical nucleation theory, we approximate the full dynamics by diffusion in a free energy potential described by an analytical expression only depending on droplet radius and reaction rate. This analogy also allows us to determine the equivalence of the binodal line, so we can propose an extension of the equilibrium phase diagram to capture driven chemical reactions. Cells might use these effects to control the nucleation of intracellular droplets.