SKM 2023 – scientific programme

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CPP: Fachverband Chemische Physik und Polymerphysik

CPP 56: Focus: Self-Assembly of Plasmonic Nanostructures (joint session CPP/HL)

CPP 56.8: Invited Talk

Friday, March 31, 2023, 12:00–12:30, GÖR 226

single molecule detection on a smartphone microscope enabled by DNA origami biosensors — •Philip Tinnefeld — Department of Chemistry and Center for NanoScience, Ludwig-Maximilians-Universität München, Butenandtstr. 5-13, 81377 München, Germany

DNA nanotechnology and especially the DNA origami technique allow well-defined assembly of optically active components and sensing units for novel biosensing approaches. We here demonstrate single-molecule detection on a battery driven smartphone microscope enabled by fluorescence enhancement with DNA origami nanoantennas. As further examples, we show DNA origami membrane sensors for curvature and membrane potentials. Finally, DNA origamis are used for a novel superresolution approach combining graphene energy transfer, pMINFLUX and DNA PAINT that enables nanometric 3D superresolution close to the coverslip.