SKM 2023 – wissenschaftliches Programm
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CPP: Fachverband Chemische Physik und Polymerphysik
CPP 57: Complex Fluids and Colloids, Micelles and Vesicles II (joint session CPP/DY)
CPP 57.7: Vortrag
Freitag, 31. März 2023, 11:30–11:45, MER 02
Inverse ISAsomes in biocompatible oils - formulation and characterisation — •Florian Trummer1, Otto Glatter2, and Angela Chemelli2 — 1Universität Stuttgart, Institut für Physikalische Chemie, Pfaffenwaldring 55, 70569 Stuttgart, Deutschland — 2Technische Universität Graz, Institut für Anorganische Chemie, Stremayrgasse 9, 8010 Graz, Österreich
In contrast to their more common counterparts in aqueous solutions, inverse ISAsomes (internally self-assembled somes/particles) are formulated as kinetically stabilised dispersions of hydrophilic, lyotropic liquid-crystalline phases in non-polar oils. This contribution reports on their formation in bio-compatible oils and their structural characterisation with Small Angle X-Ray Scattering (SAXS), Dynamic Light Scattering (DLS) and optical microscopy [1]. By using these methods, we were able to demonstrate the presence of inverse hexosomes, inverse micellar cubosomes (Fd3m) and an inverse emulsified microemulsion in squalane with a polyethylene glycol (PEG) alkyl ether as the primary surfactant forming the internal self-assembled phase, which was stabilised by hydrophobised silica nanoparticles. Furthermore, an emulsified L1-phase and inverse hexosomes were formed in triolein with the triblock-copolymer Pluronic P94 as the primary surfactant. In this case, stabilisation was achieved with a molecular stabiliser of type PEG-dipolyhydroxystearate. Finally, triolein was replaced with olive oil which also led to the successful formation of inverse hexosomes.
[1] Trummer, F., Glatter, O. & Chemelli, A. Nanomaterials 12, 1133 (2022)