SKM 2023 – scientific programme

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DY: Fachverband Dynamik und Statistische Physik

DY 52: Statistical Physics of Biological Systems II (joint session BP/DY)

DY 52.9: Talk

Friday, March 31, 2023, 11:45–12:00, BAR Schö

A possible application of the Physics of topological defects to oncology — •Andy Manapany, Leïla Mouddene, Sébastien Fumeron, Bertrand Berche, and Loriane Didier — Université de Lorraine

We propose a numerical study of the thermal diffusion process in non-Euclidian geometry applied to biological active matter. Thanks to the similarities displayed by both nematic and cells in biological tissue, we aim to apply results derived from the study of diffusion processes around topological defects found in liquid crystals, in order to highlight the thermal response in the vicinity of certain disclination defects found in epithelial tissues. This work is motivated by the fact that these types of disclination defects, mainly "comet" and "trefoil" systematically appear during metastatic phases in some forms of aggressive cancers. Thus, a study of the thermal footprint in such mediums may give us information on the most efficient ways to perform thermal ablation targeted towards aforementioned cells while preserving healthy surrounding tissue.