SKM 2023 – scientific programme

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MA: Fachverband Magnetismus

MA 23: Poster Magnetism I

MA 23.28: Poster

Tuesday, March 28, 2023, 17:00–19:00, P1

Biomarker detection using Frequency Mixing Magnetic Detection Technique — •Faranak Eivazi and Hans-Joachim Krause — Institute of Biological Information Processing (IBI-3), Forschungszentrum Jülich

Superparamagnetic nanoparticles (SPNs) with non-hysteretic magnetization curves have significant potential for biomarker detection. The aim of our study is to probe the binding states of targets to SPNs using the frequency mixing magnetic detection technique (FMMD) [1]. As the SPNs bind to the target, the change in the hydrodynamic radius of the system leads to a longer Brownian relaxation time. The FMMD exposes SPNs bound to their targets to 2 alternating magnetic fields. The low-frequency field f₂ with high amplitude drives the SPNs to saturation, and a high-frequency field f₁ with low amplitude is used to probe the nonlinear magnetization. The response of the particles induces a voltage in the detection coil. The demodulated frequency mixing harmonics f₁+nf₂ are characteristic of particle properties. The hydrodynamic radius of SPNs can be determined by observing a phase shift toward lower frequencies caused by the longer Brownian relaxation of the particles. This method can be used to determine the quantity and size of the target in the sample. [1] S. Achtsnicht, et al., PLoS ONE, 14(7), 2019.