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SOE: Fachverband Physik sozio-ökonomischer Systeme
SOE 15: Networks: From Topology to Dynamics III (joint session SOE/DY)
SOE 15.3: Vortrag
Donnerstag, 30. März 2023, 10:30–10:45, ZEU 260
On the role of deleterious mutant regime in steering long-term evolution — •Nikhil Sharma1, Joachim Krug2, and Arne Traulsen1 — 1Department of Evolutionary Theory, Max Planck Institute for Evolutionary Biology, 24306 Plön, Germany — 2Institute for Biological Physics, University of Cologne, Köln, Germany
Evolutionary Graph Theory aims to understand the interplay of natural selection and genetic drift on spatial structures. A spatial structure is modeled as a graph with nodes representing asexually reproducing individuals, and edges dictate the interaction among these individuals. Based on the fixation probabilities of mutants on graphs, graphs are mainly categorised as amplifiers of selection and suppressors of selection. We study Moran Birth-death origin fixation dynamics on graphs, see https://doi.org/10.1073/pnas.2205424119. As expected, amplifiers of selection attain higher steady-state average fitness than the complete graph. However, we found that a suppressor of fixation, having a lower probability of fixing mutants regardless of their fitness values compared to the complete graph, beats the complete graph in the long term by attaining higher average fitness. It happens because of the suppressor’s ability to reject deleterious mutants more efficiently. Similarly, an amplifier of fixation, a structure with a higher probability of fixing mutants regardless of their fitness values, attains lower steady-state average fitness. It happens because of the amplifier’s poor ability to reject deleterious mutants. These two examples illustrate the importance of the deleterious mutant regime in steering long-term evolution, which, to our knowledge, has been overlooked in the literature.