SMuK 2023 – wissenschaftliches Programm
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P: Fachverband Plasmaphysik
P 15: Laser Plasmas II/Low Pressure Plasmas and their Applications II
P 15.1: Hauptvortrag
Donnerstag, 23. März 2023, 14:00–14:30, CHE/0089
Tumor irradiation in mice with a laser-accelerated proton beam — •Florian Kroll1, Florian-Emanuel Brack1, Elke Beyreuther1,2, Thomas Cowan1,3, Leonhard Karsch1,2, Josefine Metzkes-Ng1, Jörg Pawelke1,2, Marvin Reimold1,3, Ulrich Schramm1,3, Tim Ziegler1,3, and Karl Zeil1 — 1Helmholtz- Zentrum Dresden-Rossendorf, Dresden, Germany — 2OncoRay - National Center for Radiation Research in Oncology, Dresden, Germany — 3Technische Universität Dresden, Dresden, Germany
We report on establishing a laser-plasma-based proton research platform for user-specific small animal radiobiology studies. The Draco PW laser at Helmholtz-Zentrum Dresden-Rossendorf drives the laser-plasma accelerator (LPA). We discuss the findings that allowed us to operate our LPA proton source with unprecedented stability and long-term reliability, featuring proton energies regularly exceeding 60 MeV.
These capabilities allowed us to conduct the first radiobiological in vivo study using an LPA proton source. The pilot study was performed on human tumors in a mouse model, showing the concerted preparation of mice and laser accelerator, the dose-controlled, tumor-conform irradiation using the LPA as well as a clinical reference proton source, and the radiobiological evaluation of irradiated and unirradiated mice for radiation-induced tumor growth delay. The prescribed homogeneous dose was precisely delivered at the laser-driven source.
The presented results prove that LPA proton sources have reached a new level of applicability and now enable systematic radiobiological studies within an unprecedented range of beam parameters.