SMuK 2023 – wissenschaftliches Programm

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ST: Fachverband Strahlen- und Medizinphysik

ST 2: Medical Imaging Concepts

ST 2.6: Vortrag

Dienstag, 21. März 2023, 18:15–18:30, ZEU/0146

Experimental characterization and comparison of two Si-based compact setups for proton radiography and tomography of small animals for image-guided proton irradiation — •Angelica Noto¹, Guyue Hu¹, Katrin Schnürle¹, Matthias Würl¹, Franz Englbrecht¹, Johannes Gebhard¹, Julie Lascaud¹, Marco Pinto¹, Ze Huang¹, Jonathan Bortfeldt¹, Mateusz Sitarz², Per Poulsen², and Katia Parodi¹ — ¹Medical Physics Department, LMU, Munich, Germany — ²Danish Center for Particle Therapy, Aarhus University Hospital, Aarhus, Denmark

In the project SIRMIO we develop advanced imaging for positioning and treatment planning to aid precise proton irradiation of small animals.In contrast to the widely adopted X-ray cone beam CT, the project integrates 3 solutions of proton imaging. Here, we compare 2 approaches that provide spatially resolved detection of individual or integral proton energy deposition relying on the commercial Timepix3 or Lassena Si-based pixelated detectors. Proton radiographs were acquired at the Danish Center for Particle Therapy for a calibration phantom housing inserts of well characterized relative stopping power values. We will compare the achievable spatial resolution and accuracy of water equivalent thickness retrieval in radiographic mode for different systems and imaging doses. Moreover, ongoing acquisitions of tomography with the Timepix3 will be presented for the calibration phantom and a dedicated mouse-like phantom. The work is supported by EU through the grant agreements 725539, 730983 and 101008548. The authors would like to thank Nordson and Advacam.