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AGA: Arbeitsgruppe Physik und Abrüstung
AGA 5: Effects of Radiation
AGA 5.1: Invited Talk
Thursday, March 21, 2024, 15:00–16:00, PTB HS HvHB
Gender- and age-specific characteristics in radiosensitivity and their consequences for radiation protection - Overview of the current knowledge — Lena Winterling1,2, Laura Ruspeckhofer1,2, Tom Unterleiter1,2, Michael Rückert1,2, Thomas Weissmann1, Antonia Völlings1,2, Margaux Piltz1,2, Eva Titova1,2, Rainer Fietkau1, Udo S. Gaipl1,2, and •Lisa Deloch1,2 — 1Department of Radiation Oncology, Uniklinikum Erlangen, Friedrich-Alexander- Universität Erlangen-Nürnberg, Germany — 2Translational Radiobiology, Department of Radiation Oncology, Uniklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Germany
The main aim of radiation protection is to keep the population from damage caused by ionizing and non-ionizing radiation, whereby deterministic damage should be prevented and stochastic risks should be reduced to a minimum. Biological research relevant to radiation protection has so far mostly focused on DNA as the most radiation-sensitive component of the cell. Nevertheless, a paradigm shift has become noticeable in recent years, which not only places direct, DNA-mediated effects at the center of research, but also focuses on systemic, immune-mediated effects that also occur after exposure to radiation. Additionally, age and gender have also an impact on the immune system, a rather basic but crucial factor that has been widely neglected in research. Some of these gender-specific influences are also known for radiation exposure, where women have shown to exploit a two-fold increased risk for solid tumors than men after exposition to radiation. Similar, preclinical studies revealed gender-specific differences in DNA-mediated radiation response. A more detailed understanding of the molecular mechanisms is thus required to define more specific threshold values in radiation protection issues but also in therapeutic approaches, disarmament and dismantling processes. As these important questions have not yet been systematically investigated, our NukSiFutur workgroup is focusing on answering the influence of age and gender on radiation responses in an osteo-immunological setting.
Keywords: Radiation Protection; Radiation Exposure; Gender-specific Influences