Berlin 2024 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 13: Statistical Physics of Biological Systems I (joint session DY/BP)

BP 13.1: Hauptvortrag

Dienstag, 19. März 2024, 09:30–10:00, BH-N 334

Dynamics of genome replication — •Simone Pigolotti — Okinawa Institute of Science and Technology

The DNA replication program of an organism determines the timing at which different genomic regions are replicated, with fundamental consequences for cell homeostasis and genome stability. I will present a method to infer the DNA replication program, by combining stochastic modeling and deep sequencing experiments. Our approach can be applied to a vast range of organisms from bacteria to eukaryotes. Applied to E. coli, our method reveals regular variations of replication speed, that correlate with previously measured variations of the mutation rate. In budding yeast, our method is able to infer the location of replication origins with remarkable accuracy.

Keywords: Stochastic Dynamics; DNA replication; Escherichia coli; Budding yeast