Bereiche | Tage | Auswahl | Suche | Aktualisierungen | Downloads | Hilfe

BP: Fachverband Biologische Physik

BP 14: Poster IIa

BP 14.12: Poster

Dienstag, 19. März 2024, 18:00–20:30, Poster E

Unraveling Morphogen Dynamics and Growth Mechanisms in Zebrafish Pectoral Fin through Mathematical Modeling — •Maximilian Kotz¹, Benjamin M. Friedrich¹, Lucas de Oliveira Petrocchi Ribas², and Rita Mateus² — ¹TU Dresden — ²MPI-CBG, Dresden

During animal development and regeneration, morphogen gradients control tissue growth and patterning. Here, we study mechanisms of growth control using the pectoral fin of zebrafish as model system. A key open question is whether morphogen function similarly in development and regeneration. To address this question, we build data-driven mathematical models of morphogen dynamics coupled to growth. We quantitatively compare finite-element simulations of the models to time-lapse microscopy data provided by our experimental collaborators. For this, we use AI-based image analysis for nuclei segmentation, as well as curved coordinate systems to unwrap the curved 3D tissue geometry. Ultimately, we aim to delineate similarities and differences between development and regeneration, with respect to growth control by morphogens.

Keywords: Morphogens; Zebrafish; Regeneration; Theory; Simulation