Berlin 2024 – scientific programme
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BP: Fachverband Biologische Physik
BP 14: Poster IIa
BP 14.18: Poster
Tuesday, March 19, 2024, 18:00–20:30, Poster E
Mechanobiological response of an epithelial tissue under shear stress — •Narmin Abasova1, Annemarie Wirth1, Kevin Hoellring1, Rudolf Merkel2, and Ana-Sunčana Smith1,3 — 1PULS Group, Institute for Theoretical Physics, FAU Erlangen- Nurnberg (IZNF) — 2Institute for Biological Information Processes (IBI), Forschungszentrum, 52428 Jülich, Germany — 3Group of Computational Life Sciences, Division of Physical Chemistry, Ruder Bošković Institute, 10000 Zagreb, Croatia
Epithelial cells endure a continuous array of mechanical stresses within the human body, from the rhythmic pulsations of blood circulation to the dynamic stresses induced by exercise. Understanding the mechanobiological aspects of stress generation in epithelial cells is crucial for unraveling the complex dynamics underlying cellular responses and tissue functionality. Hence, we employ stress-generating devices to investigate the effects of distinct stress types on the tissue.The influence of solid shear stress transmitted through the extracellular matrix (ECM) remains a less-explored frontier in tissue mechanics. This research employs a custom-made device capable of applying controlled shear stress to the substrate supporting epithelial cell cultures. Upon subjecting the studied cluster to solid shear stress, we systematically document the tissue's response to the applied stress under the microscope. Our investigation delves into the implications of solid shear stress on cellular behavior, encompassing analyses of cell elongation, proliferation, stress relaxation, and the T1 transitions at the cell membrane, where neighbor exchanges occur.
Keywords: Epithelial cells; Shear stress; Tissue mechanics; Stress relaxation; Mechanobiology