Berlin 2024 – scientific programme
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BP: Fachverband Biologische Physik
BP 14: Poster IIa
BP 14.2: Poster
Tuesday, March 19, 2024, 18:00–20:30, Poster E
Improving Sensitivity of Micro-Ring Resonators for Photonic Biosensors — •Philipp Schrenk1, Anders Henriksson1, Christopher Borgmeier1, Peter Neubauer1, and Mario Birkholz2 — 1Department of Bioprocess Engineering, Institute of Biotechnology, Technical University Berlin, Ackerstr. 76, ACK24, D-13355 Berlin, Germany — 2IHP GmbH, Im Technologiepark 25, 15236 Frankfurt (Oder), Germany
Silicon-based photonic biosensors represent a promising approach for the detection of various pathogens. Utilizing micro-ring resonator chips, assisted by dielectrophoresis and specific antibody coatings, enables label-free detection of a sample, such as Legionella pneumophila, already at concentrations below the limit value of 100 CFU/100 ml. In contrast to conventional methods for detecting Legionella cells, photonic biosensors are cost-efficient, have a small footprint of a few mm2, and notably, possess the capability to deliver real-time results. The measuring principle of photonic biosensors relies on the evanescent field and variations of the refractive index n associated with the sample adjacent to the waveguide. In this study, the sensitivities of five different micro-ring resonators were analyzed by employing solutions with varying NaCl concentrations. These solutions induce differences in n measured in refractive index units (RIU) and consequently affect the evanescent field. By variation of the chip architecture, the sensitivities could be increased from 3.6 up to 23.5 nm/RIU. These findings are crucial for further quantitative investigations in detecting Legionella pneumophila cells.
Keywords: Biosensors; Micro-Ring Resonators; Dielectrophoresis; Legionella pneumophila; Evanescent Field