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BP: Fachverband Biologische Physik
BP 14: Poster IIa
BP 14.8: Poster
Tuesday, March 19, 2024, 18:00–20:30, Poster E
Modeling of antibiotic-induced perturbation in gut microbiome — •Rie Maskawa1, Hideki Takayasu1, Lena Takayasu2, Wataru Suda2, and Misako Takayasu1 — 1Tokyo Institute of Technology, Tokyo, Japan — 2RIKEN, Yokohama, Japan
It is important to understand the fluctuation of microbiome due to external perturbations. However, detailed microbiome response to perturbations has not been quantitatively evaluated. We analyzed high-resolution time series of the gut microbiome of mice receiving different concentrations of the antibiotics using the extended Lotka-Volterra model. By modeling of the antibiotic change based on a pharmacokinetic model, detailed temporal changes of perturbation were incorporated into the model. As a result of identifying parameters that accurately describe the kinetics and extracting robustly estimated bacterial interactions between mice, we concluded that the interbacterial network may change depending on the antibiotic pharmacokinetics.