Berlin 2024 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 14: Poster IIa
BP 14.8: Poster
Dienstag, 19. März 2024, 18:00–20:30, Poster E
Modeling of antibiotic-induced perturbation in gut microbiome — •Rie Maskawa1, Hideki Takayasu1, Lena Takayasu2, Wataru Suda2, and Misako Takayasu1 — 1Tokyo Institute of Technology, Tokyo, Japan — 2RIKEN, Yokohama, Japan
It is important to understand the fluctuation of microbiome due to external perturbations. However, detailed microbiome response to perturbations has not been quantitatively evaluated. We analyzed high-resolution time series of the gut microbiome of mice receiving different concentrations of the antibiotics using the extended Lotka-Volterra model. By modeling of the antibiotic change based on a pharmacokinetic model, detailed temporal changes of perturbation were incorporated into the model. As a result of identifying parameters that accurately describe the kinetics and extracting robustly estimated bacterial interactions between mice, we concluded that the interbacterial network may change depending on the antibiotic pharmacokinetics.
Keywords: microbiome; Lotka-Volterra model; perturbation