Berlin 2024 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 15: Poster IIb

BP 15.7: Poster

Dienstag, 19. März 2024, 18:00–20:30, Poster F

Functionalization of carbon nanoparticles for a cellular application — •Carla Sprengel, Lennard Fastabend, Cathrin Nollmann, and Thomas Heinzel — Condensed Matter Physics Laboratory, Heinrich Heine University, Düsseldorf, Germany

Nanoparticles as carriers in drug delivery systems are gaining in interest in the field of cancer therapies. Transporting drugs directly into targeted cells could enhance the efficiency and reduce side-effects in therapy. The carbon nanodots presented here show promise as potential carriers because of their low cytotoxicity and cellular uptake via endocytosis. Furthermore, the particles can be localized on a cellular level due to their fluorescence properties. Since an effective functionalization of our particles is crucial for the application in drug-delivery systems, we tested our particles as carriers by binding a polymer to them. Here we present the successful functionalization of our carbon nanoparticles and a cellular uptake into the lysosomes of MCF-7 cells.

Keywords: Nanoparticles; Drug-Delivery Systems; Functionalization; Fluorescence; Live-Cell Imaging