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BP: Fachverband Biologische Physik

BP 15: Poster IIb

BP 15.8: Poster

Dienstag, 19. März 2024, 18:00–20:30, Poster F

Multifunctional Photoluminescent Quantum dots as Amplifiers for 1O2 Generation and Synergistic Enhanced Photodynamic Therapy — •Zahid Ullah Khan¹, Latif Ullah Khan², Hermi Felinto de Brito¹, and Paolo Di Mascio¹ — ¹Institute of Chemistry, University of São Paulo (USP), 05508-000, São Paulo-SP, Brazil — ²Synchrotron-light for Experimental Science and Applications in the Middle East (SESAME) P.O. Box 7, Allan 19252, Jordan.

The development of multi-functional nano-platform with integrated diagnostic and therapeutic features is highly desired for precise treatment. Here, we report the synthesis of CdSe/ZnS core-shell QDs by new method, which exhibited wide-range color-tunability (490-570 nm). The color tuning was achieved as result of interfacial alloying (predominantly exchange of Se2- by S2- anion) without changing the size of NCs. The QDs demonstrated efficient singlet molecular oxygen (1O2) quantum yields of 14, 12, and 18% for yellow-emitting CdSe/ZnS QDs (I), green-emitting CdSe/ZnS QDs (II), and blue-emitting CdSe/ZnS QDs (III), respectively. The 1O2 was produced by QDs via triplet-triplet energy transfer to dioxygen. The QDs were studied in macrophage cells that internalized the NCs via energy-dependent endocytosis predominantly macropinocytosis and other lipid raft-mediated endocytic pathways and manifested considerable amount in the intracellular regions without causing cytotoxicity3. In summary, the study will open new possibilities of band edge engineering and pathway-specific delivery of QDs-based theranostic into a site of interest for simultaneous bioimaging and photodynamic therapy.

Keywords: Multifunctional quantum dots; Singlet molecular oxygen generation; Cellular uptake; Bioimaging; Photodynamic therapy