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BP: Fachverband Biologische Physik

BP 2: Membranes and Vesicles I

BP 2.8: Talk

Monday, March 18, 2024, 11:45–12:00, H 2032

Biomolecular condensates on geometrically structured lipid membranes — •Katja Zieske — Biophysics, Max Planck Institute for the Science of Light, Erlangen, Germany

Biomolecular condensates are supramolecular assemblies of proteins and RNA molecules and have been studied extensively, due to their ability to spatially structure cells and to spatially confine biological reactions. However, little is known about the interactions of liquid-liquid condensates with geometrically structured lipid membranes and the consequences of these interactions on cellular length scales. Here, we used a cell-free bottom-up approach to reconstitute liquid-liquid condensates at geometrically structured lipid membranes. Our results demonstrate how lipid membranes and liquid-liquid condensates interact under various experimental conditions and point towards an important role of membrane geometry-controlled wetting-effects in intracellular organization.

Keywords: Lipid membranes; biomolecular condensates; geometry; self-assembly; wetting