Berlin 2024 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 20: Poster IIIa
BP 20.21: Poster
Mittwoch, 20. März 2024, 11:00–14:30, Poster B
Phase separation on membranes with matter exchange and dimerization — •Riccardo Rossetto1, Kueyoung Kim2, and David Zwicker1 — 1Max Planck Institute for Dynamics and Self-Organization — 2Department of Chemistry, The Pennsylvania State University
Patterns form on membranes in a large variety of biological contexts. In many cases, the patterns are affected by material exchange between the membrane and the bulk. Moreover, the involved biomolecules often also form short polymers and interact unspecifically. We describe this situation with a thermodynamically consistent minimal model, which accounts for phase separation, dimerization, and material exchange between the membrane and the bulk. While these mechanisms are understood individually, interesting nonlinear effects emerge from their combination. We illustrate this by explaining experimental data from the PAR patterning system, which exhibits dimerization and membrane binding. The general conclusions from our model unveil fundamental mechanisms of pattern formation on membranes and will help us explain more biological observations in the future.
Keywords: Phase Separation; Membranes; Pattern formation; Dimerization