Berlin 2024 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 20: Poster IIIa
BP 20.23: Poster
Mittwoch, 20. März 2024, 11:00–14:30, Poster B
Probing Neuronal Dendrites by First-Passage Properties — •Fabian Hubertus Kreten1,2, Ludger Santen1,2, and Reza Shaebani1,2 — 1Department of Theoretical Physics, Saarland University, Saarbrücken, Germany — 2Center for Biophysics, Saarland University, Saarbrücken, Germany
Probing Neuronal Dendrites by First-Passage Properties
Part of the neuronal signal transmission mechanism is the dendritic tree, an arborous structure of gradually thickening channels leading to the soma. Along these channels bulbous protrusions (spines) are located at which synapses can form.
Neurodegenerative diseases alter the structure of the dendritic tree and by that perturb this finely tuned machinery. Probing the structure of a patient's dendrites could thereby give insight into the progression of the disease in question.
Previously, studies of how the structural parameters of dendritic trees influence their transport properties and how these structural properties might be regained from measurements of tracer particles have been undertaken. [1,2] In the present work we extend these studies to hypothetical tracer particles which spontaneously enter the dendritic tree, perform a random walk on the dendritic tree and when reaching the soma spontaneously decay while emitting a signal.
[1] M. Reza Shaebani et al., Phys. Rev. E 98 (4 2018)
[2] Robin Jose, Ludger Santen and M. Reza Shaebani, Biophysical Journal 115.10 (2018)
Keywords: Dendrites; First-Passage Statistics; Random Walk; Neuron; Trees