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BP: Fachverband Biologische Physik

BP 20: Poster IIIa

BP 20.28: Poster

Wednesday, March 20, 2024, 11:00–14:30, Poster B

A Study on Tradeoffs Induced Landscapes Model — •Muna Turki1, Suman Das2, Muhittin Mungan3, Rotem Gross4, and Joachim Krug51Institute of Biological Physics - University of Cologne — 2Institute of Ecology and Evolution - University of Bern — 3Institute of Biological Physics - University of Cologne — 4Institute of Biological Physics - University of Cologne — 5Institute of Biological Physics - University of Cologne

Effects mutations have on the fitness of a genotype are environment dependent. The endangering pressure of antibiotics directs bacterial cultures towards the selection of resistant mutants. These resistant mutants are equipped with mutations that increase the fitness of bacteria in the presence of antibiotics allowing for adaptation, however they come with a cost in the form of decreasing fitness in absence of antibiotics as the resistant mechanisms the mutant bacteria develop tend to be energy-costly, which is a tradeoff the mutant has to endure.

Tradeoff Induced Landscape (TIL) is a mathematical model that was motivated by antibiotic dose-response curves of Ciprofloxacin resistance in Escherichia coli strains which model evolution in a changing environment through adaptation-cost tradeoffs. The model assumes a non-epistatic accumulative effect of mutations on the fitness parameters, generating fitness landscapes with exceptionally smooth topology and high accessibility.

Recent experimental data on evolution of Escherichia coli in the context of β-lactam resistance are available through which the model could be tested and modified.

Keywords: Resistance Evolution in Bacteria; Tradeoffs; Fitness Landscape; β−lactam Resistance; Diminishing Returns Epistasis

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