Berlin 2024 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 20: Poster IIIa
BP 20.4: Poster
Mittwoch, 20. März 2024, 11:00–14:30, Poster B
Simulating a field-theoretic model of transcription condensates — •Kathrin Hertäg1, Joshua Robinson2,3, and Thomas Speck1 — 1ITP4, Stuttgart, Deutschland — 2Institut für Physik, Johannes Gutenberg-Universität Mainz, Deutschland — 3H.H. Wills Physics Laboratory, University of Bristol
Phase separation of macromolecules has recently attracted substantial interest, in particular in the context of membrane-less organelles in the cell. These organelles are typically modeled as condensates. Instead of coarsening to a fully phase separated state, such protein condensates form stable droplets of finite size in vivo. Therefore, an important question is the role of non-equilibrium processes since the physical processes underlying stable droplet behavior are not yet resolved. Here we study active model B+, a scalar field theory developed in the context of motile active matter, and employ methods of active liquid theory to explore activity as the underlying mechanism for condensate stabilization.
Keywords: Active Model B+; Transription; Simulation; Field Theory; Phase separation