Berlin 2024 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 20: Poster IIIa

BP 20.8: Poster

Mittwoch, 20. März 2024, 11:00–14:30, Poster B

Quantifying vascular morphology on a chip — •Leonie Karr, Fatemeh Mirzapour, and Karen Alim — Technische Universität München

Our human vasculature is dynamic, growing and re-organizing not only in development but continuously adapting its morphology. Yet, what determines vessel formation and branching in healthy and disease state seems complex given the multitude of contributing factors.

Our focus lies in growing a human vasculature within the controlled environment of a chip, with the goal of quantifying the flow properties of self-organized in vitro networks. Additionally, we are examining the interplay of various cell types on these self-organized morphologies. Employing image analysis techniques alongside flow simulation methods, our objective is to accurately quantify how flow and cell types determine network architecture. The results obtained from our analyses will significantly contribute to the development of next-generation therapeutics aimed at targeting vessel development.

Keywords: fluid dynamics; on-chip vasculature