Berlin 2024 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 21: Poster IIIb
BP 21.6: Poster
Mittwoch, 20. März 2024, 11:00–14:30, Poster C
Red blood cells adhesion and its Influence on capillary Flow in-vivo Microvasculature: A Simulation Study — •Mohammed Bendaoud1,2, Alexis Darras1, Yazdan Rashidi1, Christian Wagner1, and Chaouqi Misbah2 — 1Department of Experimental Physics, Saarland University, Saarbruecken 66123, Germany — 2Université Grenoble Alpes, CNRS, LIPhy, F-38000 Grenoble, France
Red blood cells (RBCs) can aggregate and disassociate reversibly under normal physiological conditions. Cardiovascular diseases like hypercholesterolemia and diabetes have been associated with increased RBC aggregation. Fibrinogen is the main cause of this aggregation. The normal range for human fibrinogen levels is 1.8 - 4 mg/ml. Diabetes can cause stable aggregates to form, leading to vessel blockages. This study aims to investigate the influence of adhesion between red blood cells and between RBCs and vessel walls on their behaviour in blood vessel networks. This encompasses RBC and plasma distribution, blood flow rate, and RBC lingering. Studying adhesion's impact on RBC behaviour is crucial for comprehending the intricate dynamics of blood flow in microvessels. We employ the lattice Boltzmann method in 2D to simulate RBCs behaviour with adhesion in a complex vascular network.
Keywords: Red Blood Cells; Adhesion; Microvasculature; Numerical Simulation; Blood flow