Berlin 2024 – scientific programme
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BP: Fachverband Biologische Physik
BP 21: Poster IIIb
BP 21.7: Poster
Wednesday, March 20, 2024, 11:00–14:30, Poster C
Simulating tumor-induced angiogenesis using Cells in Silico — •Eric Behle1, Julian Herold2, and Alexander Schug1 — 1NIC Research Group Computational Structural Biology, Jülich Supercomputing Centre, Jülich Research Center, Jülich, Germany — 2Steinbuch Centre for Computing, KIT, Karlsruhe
Cancer remains an inadequately understood ailment affecting humanity. Its treatment poses a challenge due to tumor variability and a tumor’s impact on the surrounding environment. Tumor-induced angiogenesis is a concerning aspect of the disease. Here, a hypoxic tumor secretes growth factors, which prompts nearby blood vessel branching and successive growth toward the tumor. To study this process on a computational level, we turned to Cells in Silico (CiS), a high performance framework for large-scale tissue simulation previously developed by us. Combining a cellular Potts model and an agent-based layer, CiS is capable of simulating tissues composed of tens of millions of cells, while accurately representing many physical and biological properties. Our ultimate objective is to construct a cellular digital twin of a tumor, and integrating a realistically evolving nutrient environment is crucial. Hence, we have implemented tumor-induced blood vessel growth into CiS, and have studied the behavior of tumors placed in different environments. With this we aim to explore questions regarding hot spots for tumor growth within the body.
Keywords: Tissue simulations; Cancer physics; Angiogenesis