Berlin 2024 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 26: Biopolymers, Biomaterials and Bioinspired Functional Materials (joint session CPP/BP)

BP 26.11: Vortrag

Donnerstag, 21. März 2024, 12:30–12:45, H 0111

Arylazopyrazole Amphiphiles as New Candidates for Photo-Induced Drug Delivery — •Ipsita Pani, Michael Hardt, Dana Glikman, and Björn Braunschweig — Institute of Physical Chemistry, University of Münster, 48149 Münster, Germany

Photo-responsive materials have been extensively explored to meet the demands for high precision drug delivery. Azobenzene-based amphiphiles have been the focal point of research in photo-responsive drug delivery systems. However, most azo amphiphiles suffer from low thermal stabilities of the cis-isomer. Consequently, the drug carriers are subjected to prolonged and periodic UV irradiation of high intensity for the release of the encapsulated drug. Therefore, the design of nanocarriers for light-induced drug delivery demands innovations to achieve targeted release at low intensities and short exposure times of the UV irradiation. Arylazopyrazoles (AAPs) have emerged as novel photoswitches with superior thermal stability of the cis-isomer and photo-stationary states (>90%) for trans/cis photo-isomerization in both directions.[1,2] In this contribution, we report on the potential of an anionic AAP surfactant (octyl arylazopyrazole butyl sulfonate) as a micellar nanocarrier for doxorubicin which is the most widely used anti-cancer drug. Using surface specific tools such as surface tensiometry and vibrational sum-frequency generation (SFG) spectroscopy we demonstrate the UV-induced release of doxorubicin at the air-water interface, while the release of doxorubicin in aqueous solution is studied by UV-visible and fluorescence spectroscopy. [1] Hardt et al. Langmuir 2023, 39, 5861 [2] Honnigfort et al. Chem. Sci. 2020, 11, 2085

Keywords: Responsive interfaces