Berlin 2024 – scientific programme

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BP: Fachverband Biologische Physik

BP 26: Biopolymers, Biomaterials and Bioinspired Functional Materials (joint session CPP/BP)

BP 26.1: Invited Talk

Thursday, March 21, 2024, 09:30–10:00, H 0111

Self-organized protein/polysaccharide nano-assemblies for applications in biomedical and food sciences — •Aristeidis Papagiannopoulos — Theoretical and Physical Chemistry Institute, National Hellenic Research Foundation, 48 Vass. Constantinou Ave. 11635 Athens, Greece

Multifunctional nanocarriers of drugs and nutrients are very important for applications in the food industry and pharmaceutics. Proteins and polysaccharides are extensively used in these fields as they are biodegradable, metabolizable, nontoxic and biocompatible. Nanostructures from these two biopolymer classes combine the multifunctionality of the proteins (hydropathy and pH-dependent charge surface distributions) with the hydrophilicity and hydrogen-bonding property of the polysaccharides. Our recent work on protein/polysaccharide nanoparticles by electrostatic self-organization and thermal treatment without the use of chemical reactions or toxic solvents will be presented. Examples will include fibrinogen-hyaluronic acid nanoformulations, bovine serum albumin-chondroitin sulfate or -xanthan nanoparticles, trypsin- and hemoglobin-based nanoparticles. The discussion will be focused on the stimuli-response, molecular interactions and hierarchical morphology of the protein/polysaccharide systems and the binding of bioactive compounds. Physicochemical characterization and optimization of the nano-assemblies by light scattering, small angle scattering and spectroscopy techniques will be analyzed. These works motivate the development of other novel protein/polysaccharide biomaterials.

Keywords: nanostructured biomaterials; nanogels; proteins; polysaccharides; scattering