Berlin 2024 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 28: Cytoskeleton
BP 28.2: Vortrag
Donnerstag, 21. März 2024, 09:45–10:00, H 2032
Transient contacts between filaments bestow its elasticity to branched actin — Mehdi Bouzid1,2, Cesar Valencia Gallardo3, Magdalena Kopec3, Giuseppe Foffi4, Julien Heuvingh3, Olivia du Roure3, and •Martin Lenz2,3 — 13SR, CNRS, Université Grenoble Alpes, France — 2LPTMS, CNRS, Univ. Paris-Sud, Université Paris-Saclay, 91405 Orsay, France — 3Laboratoire de Physique et Mécanique des Milieux Hétérogènes, UMR 7636, CNRS, ESPCI Paris, PSL — 4LPS, CNRS, Univ. Paris-Sud, Université Paris-Saclay, 91405 Orsay, France
The biologically crucial elasticity of actin networks is usually understood as an interplay between the bending and stretching of its filaments. This point of view however fails when applied to the weakly coordinated branched actin networks found throughout the cell. Through experiments and theory, we show that their elasticity crucially involves reversible entanglements between their filaments. These entanglements can in turn be controlled during network growth to regulate the final properties of the network. These properties could be key to understanding how moving cells dynamically adapt their cytoskeleton to their environment.
Keywords: Actin; Network mechanics; Soft Matter; Theory