Berlin 2024 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 29: Statistical Physics of Biological Systems II (joint session BP/DY)
BP 29.9: Vortrag
Donnerstag, 21. März 2024, 11:45–12:00, H 1028
How do particles with complex interactions self-assemble ? — •Lara Koehler1, Martin Lenz2, and Pierre Ronceray3 — 1Max Planck Institute for the Physics of Complex Systems — 2Université Paris Saclay — 3Aix Marseille Université
In living cells, proteins self-assemble into large functional structures based on specific interactions between molecularly complex patches. Due to this complexity, protein self-assembly results from a competition between a large number of distinct interaction energies, of the order of one per pair of patches. Current self-assembly models however typically ignore this aspect, and the principles by which it determines the large-scale structure of protein assemblies are largely unknown. Here, we use Monte-Carlo simulations and machine learning to start to unravel these principles. We observe that despite widespread geometrical frustration, aggregates of particles with complex interactions fall within only a few categories that often display high degrees of spatial order, including crystals, fibers, and micelles. We then successfully identify the most relevant aspect of the interaction complexity in predicting these outcomes, namely the particles' ability to form periodic structures. Our results provide a first characterization of the rich design space associated with identical particles with complex interactions, and could inspire engineered self-assembling nanoobjects as well as help understand the emergence of robust functional protein structures.
Keywords: self-assembly; protein aggregation; lattice model