Berlin 2024 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 32: Tissue Mechanics II
BP 32.6: Vortrag
Donnerstag, 21. März 2024, 16:30–16:45, H 2032
Growth arrest and scaling during axolotl limb regeneration — •Natalia Lyubaykina1, 2, Pietro Tardivo3, Dunja Knapp4, Tatiana Sandoval-Guzmán4, Elly Tanaka3, and Benjamin M Friedrich1, 2 — 1Cluster of Excellence 'Physics of Life', Technical University Dresden, Dresden, Germany — 2Center for Advancing Electronics, Technical University Dresden, Dresden, Germany — 3Research Institute of Molecular Pathology, Vienna Biocenter (VBC), Vienna, Austria — 4CRTD/Center for Regenerative Therapies, Technical University Dresden, Dresden, Germany
Axolotl can regenerate lost limbs even as adults, posing the question of how a regenerating limb matches animal size, which can differ up to five-fold between juvenile and adult axolotl. Two key morphogens, SHH and FGF8, are known to regulate proliferation and growth. Yet it remains unclear how these morphogens control growth arrest once a correct target size of the wound tissue (blastema) is reached. Inspired by this biological example, we theoretically investigate growth arrest during blastema growth and address the question of proportional growth matching animal size. Using a minimal reaction-diffusion model, we describe SHH and FGF8 dynamics during regeneration and formulate French flag-like growth rules to discern conditions for robust growth arrest during tissue growth. We also explore how a putative scaling of SHH or FGF8 morphogen gradients with either blastema or animal size impacts growth arrest and proportional growth. Finally, we compare theory predictions to recent quantifications of SHH and FGF8 morphogen gradients.
Keywords: Tissue patterning; Scaling; SHH and FGF8 morphogens; Limb regeneration; Axolotl