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BP: Fachverband Biologische Physik
BP 36: Cell Mechanics II
BP 36.5: Talk
Friday, March 22, 2024, 11:00–11:15, H 0112
Electron UHDR and FLASH radiation biology studies at PITZ, DESY — •Yuliia Komar1,2, Anna Grebinyk1,2, Marcus Frohme1, Frank Stephan2, Zakaria Aboulbanine2, Namra Aftab2, Zohrab Amirkhanyan2, Aida Asoyan2, Prach Boonpornprasert2, Paul Borchert1, Hakob Davtyan2, Dmytro Dmytriiev2, Georgi Georgiev2, Matthias Gross2, Andreas Hoffmann2, Mikhail Krasilnikov2, Xiangkun Li2, Max Liebel2, Zahra Lotfi2, Frieder Mueller2, Anne Oppelt2, Aleksandar Radivoievych1, Chris Richard2, Felix Riemer2, Houjun Qian2, Grygorii Vashchenko2, and Daniel Villani2 — 1Technical University of Applied Sciences Wildau, Wildau, Germany, — 2Deutsches Elektronen-Synchrotron, Zeuthen, Germany
The Photo Injector Test facility at DESY in Zeuthen (PITZ) together with the Technical University of Applied Sciences Wildau are going to study ultra-high dose rate (UHDR) cancer radiation therapy (RT) at FLASHlab@PITZ. FLASH RT is based on UHDR irradiation (40-10^9 Gy/s) and was shown to have a higher sparing effect on normal tissue in comparison to conventional dose rate (0.05 Gy/s) applied in clinics. The unique parameter space of the PITZ beam allows to deliver dose rates in the range between 0.05 Gy/s and 10^14 Gy/s, providing a unique possibility to investigate the effect of dose rate escalation and contribute to widening of the RT therapeutic window. For that matter, the in vitro effect of UHDR was studied at FLASHlab@PITZ. The obtained data demonstrated ROS generation, DNA damage and cell proliferation decrease at increasing doses for both UHDR 10^5 Gy/s and conventional 0.05 Gy/s. The obtained first results highlighted the potential to explore UHDR further for cancer RT.
Keywords: Radiotherapy; FLASH; Ultra-high dose rate; Cancer; Radiobiology