Berlin 2024 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 36: Cell Mechanics II
BP 36.6: Vortrag
Freitag, 22. März 2024, 11:15–11:30, H 0112
Electrohydraulics of electrically polarized spherical organoids — •Amit Singh Vishen1, Ahandeep Manna1, Jacques Prost2, and Frank Julicher1 — 1Max Planck Institute for the Physics of Complex Systems, Dresden — 2Laboratoire Physico-Chimie, Institut Curie, Paris, France
Cells and tissues in many contexts are electrically polarized. We develop a three-dimensional electro-hydraulic model that simultaneously solves for the electric potential, ion concentration, and hydrodynamic flows and stresses inside and outside a spherical water-filled cavity enclosed by an epithelium. We analyze two sources of electric asymmetry in the system: (i) heterogeneous ion transporter along the surface of the sphere and (ii) organoid in an external electric field. We show that inho- mogeneous ion transport leads to an organ-scale electric current and water flux. Consistent with recent experimental observation we find that a constant electric field leads to isotropic swelling of the organ.
Keywords: Electrohydraulics; Ion transport; Organoid; Self-propulsion