Berlin 2024 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 4: Computational Biophysics I
BP 4.10: Vortrag
Montag, 18. März 2024, 17:30–17:45, H 0112
Radial dependence of X-ray induced ionization clusters around a gold nanoparticle — •Leo Thomas1,2, Hans Rabus1, and Miriam Schwarze1 — 1National Metrology Insititute, Berlin Germany — 2Dept. II, Technical University of Berlin, Germany
One strategy to improve the efficacy of radiotherapy for cancer is increasing the tumor*s sensitivity to irradiation, e.g., by introducing gold nanoparticles (GNPs) into cancer cells [1].
This work explores the enhancement of ionization clusters around a GNP, which are considered to be indicative of the induction of DNA lesions [2], a potential trigger for cell-death-inducing damage [3].
Monte Carlo track structure simulations were performed in a two-step-approach. The produced ionizations were scored using Associated Volume Clustering [4] to obtain the radial profile of ionization clusters frequency.
The influence of the GNP on the electron fluence spectrum is relatively small and occurs mainly at energies below 10 keV. Accordingly, increased ionization clustering is limited to a range up to about 200 nm. Here, smaller GNPs (radii up to 10 nm) cause noticeable peaks in the frequency ionization clusters upon occurrence of a photon interaction at distances around 50 nm from the GNP surface.
[1] J. Hainfeld et al.,Nanomedicine (Lond), 8 (2013) 1601-9 [2] A. Rucinski et al., Phys Med Biol, 66 (2021) 24TR01 [3] M. Lomax et al., Clin Oncol, 25 (2013) 578-85. [4] K. R. Kase et al., The dosimetry of ionizing radiation Vol 1 (1985) Chap. 2
Keywords: Simulation; Monte Carlo; Radiatio therapy; Medical Physics; Nanodosimetry