Berlin 2024 – scientific programme
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BP: Fachverband Biologische Physik
BP 5: Tissue Mechanics I
BP 5.2: Talk
Monday, March 18, 2024, 15:15–15:30, H 0110
The fluid mechanics of the first folding event of the zebrafish forebrain — Angus Inman1, Judith E. Lutton2, Elisabeth Spiritosanto1, Masazumi Tada3, Till Bretschneider2, •Pierre A. Haas4,5,6, and Michael Smutny1 — 1Centre for Mechanochemical Cell Biology and Division of Biomedical Sciences, Warwick Medical School, University of Warwick — 2Department of Computer Science, University of Warwick — 3Department of Cell and Developmental Biology, University College London — 4Max Planck Institute for the Physics of Complex Systems — 5Max Planck Institute of Molecular Cell Biology and Genetics — 6Center for Systems Biology Dresden
The formation of complex tissues during development relies on robust spatiotemporal coordination of mechanical forces between different tissues or in complex geometries.
Here, I will show how such inter-tissue forces underpin the first folding event in the developing zebrafish forebrain [bioRxiv:2023.06.21. 545965v1]. I will develop a fluid mechanical model of tissue flows during zebrafish gastrulation to identify the minimal set of spatiotemporally varying regularised force singularities required to reproduce the topological features of the observed tissue flows qualitatively. I will then discuss how we have tested these predictions in vitro and in silico: I will show in particular that this minimal set of singularities is also sufficient to reproduce the observed tissue flows quantitatively and I will explain how our combined experimental and theoretical results show that the coordination of different mechanical processes in different tissues is required for correct folding of the zebrafish forebrain.
Keywords: fluid mechanics; regularised singularities; tissue folding