Berlin 2024 – scientific programme

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BP: Fachverband Biologische Physik

BP 8: Poster Session Ia

BP 8.11: Poster

Monday, March 18, 2024, 18:00–20:30, Poster C

Mechanical properties of microtubule in actin network — •Komal Bhattacharyya, Sarah Köster, and Stefan Klumpp — University of Göttingen, Göttingen, Germany

The cytoskeleton provides structural support and facilitates dynamic cellular processes such as growth and migration. Actin and microtubules are key components of the cytoskeleton. Actin, characterized by its semi-flexible nature, contrasts with the stiff, rod-like structure of microtubules. The synergy between these two elements plays a pivotal role in numerous biological phenomena. For instance, microtubules exhibit enhanced resistance to compressive forces when integrated into an actin network. In our research, we use Cytosim[1] to simulate the networks formed by actin and microtubules. Specifically, we analyze the buckling behavior of microtubules under varying compressive forces. The objective is to unravel the specific interactions between actin and microtubules that contribute to the observed mechanical responses within composite networks.

[1] Francois Nedelec and Dietrich Foethke 2007 New J. Phys. 9 427

Keywords: Numerical simulation; Cell mechanics; Composite network