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BP: Fachverband Biologische Physik
BP 8: Poster Session Ia
BP 8.18: Poster
Monday, March 18, 2024, 18:00–20:30, Poster C
Flow Dynamics in the Capillary Network of Different Blood Cell Types — •khadija larhrissi1, Christian Wagner1, Felix Milan Maurer1, Selina Wrublewsky2, Yazdan Rashidi1, Alexis Darras1, and Matthias Laschke2 — 1Department of Experimental Physics, University Campus, Saarland University, 66123 Saarbrucken, Germany — 2Institute for Clinical and Experimental Surgery, Saarland University, 66421 Homburg, Germany
Red blood cells (RBCs) constitute the majority of cells in the blood and play a key role in transporting oxygen to tissues and organs. On the other hand, leukocytes, also known as white blood cells, make up approximately 1% of the total blood volume in most mammals. The flow of these cells ensures the body's defence against various viral and bacterial infections. The White blood cells (WBCs) exhibit two modes of motion: a fast flow mode where they move with the surrounding fluid, and a slower rolling mode where they partly adhere to the wall, whereas Red Blood Cells (RBCs) simply flow with the surrounding fluid.
In this study, our objective is to examine the influence of geometry and distribution on the flow of white blood cells (WBCs) and to explore how the rigidity of red blood cells (RBCs) alters flow dynamics. To achieve this, we used Golden Syrian Hamsters as a model system to quantify the flow of cells by fluorescence microscopy and compare their behavior in different networks of vessels. Additionally, since some WBCs are larger in size than the capillaries they pass through, we will examine the impact of this size difference on their flow.
Keywords: hamster; white blood cells; Red blood cells; flow dynamics; capillary network