Berlin 2024 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 9: Poster Session Ib
BP 9.4: Poster
Montag, 18. März 2024, 18:00–20:30, Poster D
Spatially varying cell fitness induced by confinement geometry and alignment — •Patrick Zimmer1,2, Yoav G. Pollack1,2, Philip Bittihn2, and Ramin Golestanian2,3 — 1University of Göttingen, Göttingen, Germany — 2Max Planck Institute for Dynamics and Self-Organization (MPI-DS), Göttingen, Germany — 3University of Oxford, Oxford, UK
Competition of cell phenotypes for limited space plays a role in both development and in tumor progression (healthy-cancerous / cancerous-cancerous clones). We focus here on purely non-adversarial competition dominated by stochastic fluctuations, avoiding any 'killing' related advantage.
Predicting the outcome for competition of such growing active matter is non-trivial, as it depends on how cell turnover via growth, proliferation and the degradation of cellular matter is regulated by mechano-sensing in confinement.
We show that in a circular confinement, fitness of clones varies in the edge compared to the center correlated with layering, polar order of cell alignment and pressure modulation.