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CPP: Fachverband Chemische Physik und Polymerphysik
CPP 15: Poster I
CPP 15.13: Poster
Monday, March 18, 2024, 18:00–20:00, Poster C
Are alginate - pullulan sponge-like composites suitable to help heal a skin wound? — •Emma Bobu1, Klara Magyari2, Alexandra Dreanca3, and Monica Baia4 — 1Doctoral School in Physics, BBU, Cluj, Romania — 2Interdisciplinary Research Institute on Bio-Nano-Sciences, BBU, Cluj, Romania — 3Faculty of Veterinary Medicine, UASVM, Cluj, Romania — 4Faculty of Physics, BBU, Cluj, Romania
A major health issue that needs to be addressed is external bleeding, which occurs every day in people around the world, due to accidents or surgery. Normally, the body reacts immediately to stop the bleeding and heal the wound, but there are deep and uncontrolled bleedings, and the body needs external help for hemostasis. First, we need to absorb the blood and keep the wound moist. The natural polymers chosen for this purpose are calcium alginate and pullulan, because of their good swelling proprieties and biocompatibility. Therefore, the final material CAlg-Pll has a sponge-like structure that absorbs the fluid to increase the viscosity and concentration of the blood in the wound while keeping the environment moist. That stops the bleeding and prevents big losses. The samples were synthesized and characterized by XRD, FT-IR, and Raman spectroscopy. For the in vitro tests, the samples were immersed in simulated body fluid to see the bioactivity, swelling ratios, and degradability and were again investigated by XRD, FT-IR, Raman spectroscopy, and SEM. The next assay was the evaluation of coagulation rate and time. The materials are stable in biological fluid, absorb the excess fluid in the wound, and are nontoxic.
Keywords: hemostasis; biomaterials; alginate; pullulan